Australian youngster Alex de Minaur won his third title of the season at the Zhuhai Championships on Sunday, beating Adrian Mannarino 7-6 (4) 6-4 in the final to edge closer to a top-20 world ranking.
De Minaur is now three for three in finals appearances this year, including titles in Atlanta and Sydney.
Murray won his first tour-level match since having hip surgery in January when he beat Tennys Sandgren on Tuesday but couldn't follow that up despite winning the first set, as he only converted two of his nine break points.
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"It was a really tough match".
"I felt like Adrian just played better than I did in those moments", De Minaur said.
"I just tried to continue working hard because I know when you work and do as much as possible, normally you have the prize", Carreno Busta said.
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Earlier in the day, Sander Gille and Joran Vliegen took the doubles the title.
"It's our first time in China, so we didn't really know what to expect".
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De Minaur, now 31 in the world, overcame the Frenchman in a little over two hours to cap an impressive week for the 20-year-old. "I hope I am going to keep going like this in the final". "I think that we never expected this when we started in 2013, of course, but I think gradually just progressing..."