The Islamic Jihad confirmed Abu el-Atta, the commander, was killed. The house was known to be Abu el-Atta's home.
The Palestinian health ministry has meanwhile said that "a Palestinian man a woman were killed, and two more people were injured in an airstrike at a house in the eastern part of al-Shejaya in the eastern Gaza Strip".
The militant group said Abu el-Atta, 42, was undergoing "a heroic act" when he was assassinated. It did not elaborate, but vowed revenge.
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Alerts went off as far north as Tel Aviv as terrorists expressed their rage at the the loss of the terror chief.
Gaza's Hamas rulers are threatening to avenge the targeted killing of a top commander from the smaller Islamic Jihad group in the coastal strip.
He said Israel had no further plans to resume its assassinations of militant leaders - a practice that in the past has triggered heavy fighting. "There was no other choice, " Conricus said. The group said that one of its senior members had been also targeted in a suspected Israeli airstrike in Damascus, where the Palestinian group has its headquarters. Al-Ajouri's son Muath was killed, along with his granddaughter Batoul. Syrian state media identified the building as a civilian home located near the Lebanese embassy in Mezzah, a western district of the capital that is home to Damascus University and many foreign embassies. Civil defense workers were at the scene, lifting debris and tending to electricity cables.
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Just this week Netanyahu appointed hard-line politician Naftali Bennett as Israel's new defense minister.
It's a rare resumption of pinpointed targeting that threatens a new cross-border round of violence with Palestinian militants. But he hasn't taken office yet and the military said the operation had been planned long in advance.
TEL AVIV-Militants in Gaza fired at least 50 rockets into Israel early Tuesday, setting off sirens and forcing people into bomb shelters across the country including in Tel Aviv, after Israel's military killed a senior leader of the second-largest militant group in the Palestinian territory.
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The overnight attacks mark a significant escalation in the conflict between Israel and the Palestinian militant groups, which have fought each other in wars and cross-border violence for years.