But with Messi in this sort of mood, the result never felt in doubt as victory sent Barcelona back to the top of La Liga, after Atletico Madrid were held to a 1-1 draw by Alaves a couple of hours before.
The Argentine's return to full fitness is great news for Barcelona and, in particular, for Suarez. Messi plays at home, on his pitch with everything that comes with that in terms of home comforts, " Gatti told TV show "El Chiringuito de Jugones".
The forward provided four key passes, set up two goals and got a pair for himself - you can not ask for much more than that.
Real are still likely to be without Gareth Bale due to injury but have another exciting winger to call upon in 18-year-old Brazilian Rodrygo Goes, who scored his second goal for the club in the thrashing of Leganes.
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Valverde's aspect accept now obtained seven consecutive suits in all competitions, a bustle that started by beating Villarreal on September 24, when Messi returned from injury to compose his first delivery of the season.
After 10 games played, Barcelona are at the top of the league table.
Messi, however, was in an ominous mood.
Messi flicked one via the legs of Oscar Plano, who threw his head again and for a second stopped useless in frustration.
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Guardiola continued: "I was lucky enough to have him, and Xavi and [Andres] Iniesta and Dani Alves and [Gerard] Pique".
The five-time Ballon d'Or victor has endured an injury-hit start to the season after hurting his foot in August and then his thigh in September.
Suarez then finished Valladolid off, tucking away after being released by Messi's incisive pass.
In damage time, Messi ought to have had his hat-trick however curled broad of the left put up when he appeared sure to attain. It might have been his first mistake all night.
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Barca led with just two minutes played when Lenglet's strike deflected on to the crossbar and in, a kind ricochet sending the ball right to him. Another goal meant that he has scored more career club goals than Cristiano Ronaldo despite playing many less games.