Last time Williams won any Grand Slam was the Australian Open in 2017, she was a favourite contender for the cup this year too.
China's Wang Qiang will face a hard rematch with tennis legend Serena Williams in round three of the Australian Open, with the American dominating the court last time they met, at last year's U.S. Open.
Williams, who has lost four major finals and given birth to her first child then, insists she would not still be playing if she was not confident of adding to her honours list.
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The Mallorcan, the first man to be world number one in three different decades, cannot only match his great rival's achievement but also become the first man in the Open era to win all four Majors at least twice if he lifts the trophy again at Melbourne Park.
"That's something I worked on in the off-season", said Djokovic, who is gunning for a 17th Grand Slam title and his eighth in Melbourne.
The Danish player announced before the tournament that she would retire after the Australian Open and was visibly emotional at the end of the match.
In US Open 2018 she was beaten 6-2, 6-4 by Japan's Naomi Osaka in the finals.
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"I went through a couple of things, more than in NY honestly", Nadal, a four-times U.S. Open champion, said when asked about his relatively lean Australian Open record. "I'm going to do everything I can to get through that, to extend my stay here and to extend my tournament, perhaps give myself a chance to play one of the big boys". After dropping a set and winning in the Australian Open first round for the first time in his career by overcoming tenacious German Jan-Lennard Struff on Monday, Djokovic was a class above midweek. "I'm not even thinking about anything, about not being here".
It was Williams's earliest exit from the year's first Grand Slam since 2006, when her title defence was ended by Slovak Daniela Hantuchova.
But Wang held her nerve in a tense final set, securing the crucial break in the 12th and final game with her third match point.
Serena was pregnant when she won her 23rd singles Slam title in Melbourne.
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